Folate intake and prostate cancer risk: a case-control study. Shannon J, Phoutrides E, Palma A, Farris P, Peters L, Forester A, et al. S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am J Clin Nutr 2007 86:1581–5.
Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Rima Obeid, Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Building 57, 66421 Homburg/Saar, Germany, Phone: +49 8411630711, Fax: +49 8411630703, E-mail: Pfeiffer CM, Fazili Z, McCoy L, Zhang M, Gunter EW. Lowering of tHcy was predicted by baseline tHcy, but not by baseline serum or WB 5-methylTHF.Ĭorresponding author: Prof. In contrast, the increases in serum and WB 5-methylTHF were comparable between the two groups.Ĭonclusions: One year B-vitamins supplementation increased the levels of 5-methylTHF and non-methyl-folate in serum and WB, normalized tHcy, but caused an increase in the number of cases with detectable UFA in serum. 11.9 μmol/L) compared to those with baseline tHcy lower than this limit (mean 9.1 vs. A stronger reduction of tHcy after 1 year was found in participants who had baseline level >12.5 μmol/L (mean 17.0 vs. tHcy concentration was lowered after 1 year of B-vitamin supplementation (mean 13.1 vs. Unmetabolized folic acid (UFA) increased after supplementation. Also non-methyl-folate concentrations in serum and WB were higher after 6 months with B-vitamins supplementation. Results: B-vitamins supplementation for 6 months led to higher concentrations of 5-methyltetrahydrofolate (5-methylTHF) in serum (mean 49.1 vs. Serum and WB folate forms were measured before and after 6 and 12 months.
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Methods: 59 participants (mean age 67 years) were randomized to daily receive either vitamin D 3 (1200 IU), folic acid (500 μg), vitamin B 12 (500 μg), vitamin B 6 (50 mg), and calcium carbonate (456 mg) or vitamin D 3 plus calcium carbonate.
Background: We aimed to study the effect of long-term supplementation of B-vitamins on folate forms in serum and whole blood (WB) in elderly German subjects.
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